High Altitude and its Affect on Human Variation Travelling to high altitudes has a negative impact on the survival of humans that are not used to living in higher elevations. This is because the mechanisms of homeostasis in humans evolved at low altitudes. Some of the things that disturb homeostasis at high altitudes are hypoxia, more intense solar radiation, cold temperatures, aridity, wind, reduced nutrition, and rough terrain. Hypoxia can be one of the more severe disturbances to homeostasis and can be life threatening. Hypoxia is oxygen deprivation which is due to a lower concentration of oxygen at high altitudes caused by reduced barometric pressure. This type of response is more commonly seen at elevations of at least 9,000 feet and higher, though mild symptoms can be experienced at as low as 5,000 feet. The symptoms include a lack of appetite, vomiting, headache, distorted vision, ...